Description

R- 4-Oxide-4-Hydroxy-2,6-Bis([1,1':3',1''-Terphenyl]-5'-Yl)-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin is a sophisticated chiral organophosphorus compound characterized by its unique dinaphthodioxaphosphepin core and extended terphenyl substituents. This compound matters as a high-performance chiral ligand or catalyst precursor, offering exceptional stereoselectivity in asymmetric synthesis for the production of advanced pharmaceutical intermediates and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to develop novel synthetic routes with high enantiomeric purity.

Application

• Asymmetric Catalysis: Employed as a chiral ligand for transition metal-catalyzed reactions, including hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: Critical for the stereoselective construction of complex molecules in the development of new active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Material Science: Serves as a building block or dopant for creating chiral organic electronic materials or liquid crystals.
• Methodology Development: A valuable tool for academic and industrial research groups exploring new asymmetric synthetic methodologies.
• Fine Chemical Production: Applied in the commercial-scale manufacture of enantiomerically pure flavors, fragrances, and other high-value chemicals.

Basic Information

Product Name	R- 4-Oxide-4-Hydroxy-2,6-Bis([1,1':3',1''-Terphenyl]-5'-Yl)-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin
CAS No.	361342-55-4
Molecular Formula	C66H40O4P
Molecular Weight	913.00 g/mol
Synonyms	(R)-4-Hydroxy-2,6-bis([1,1':3',1''-terphenyl]-5'-yl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; R-DINAP; (R)-4-Hydroxy-2,6-bis(5''-([1,1':3',1''-terphenyl]-5'-yl))dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; Chiral Dioxaphosphepin Ligand; R-BINAP-Derived Phosphinite Oxide; (R)-HOBITP; R-4-Hydroxy-2,6-bis(terphenyl)dinaphthodioxaphosphepin 4-oxide
EINECS	Contact for details

Quality Control

Our R- 4-Oxide-4-Hydroxy-2,6-Bis([1,1':3',1''-Terphenyl]-5'-Yl)-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. Due to its sensitivity, the container should be kept sealed to prevent oxidation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.