Description

Cyclopropanecarbonyl Chloride, 1-(3-Fluorophenyl)- (9Ci) is a specialized fluorinated cyclopropane derivative, serving as a high-value building block in advanced organic synthesis. Its core value lies in enabling the precise introduction of the cyclopropane-carbonyl pharmacophore, a key structural motif known to enhance metabolic stability and binding affinity in bioactive molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used to construct advanced active ingredients for modern pesticides and herbicides, leveraging the bioactivity of the fluorinated cyclopropane ring.
• Chemical Biology & Proteomics: Employed as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal and chemical resistance properties.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, including novel cyclopropanation and fluorination strategies.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 1-(3-Fluorophenyl)- (9Ci)
CAS No.	361211-23-6
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	1-(3-Fluorophenyl)cyclopropanecarbonyl chloride; 3-Fluorophenylcyclopropanecarbonyl chloride; (3-Fluorophenyl)cyclopropanecarbonyl chloride; Cyclopropanecarbonyl chloride, 1-(3-fluorophenyl)-; 1-(3-Fluorophenyl)cyclopropanecarboxylic acid chloride; 361211-23-6
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarbonyl Chloride, 1-(3-Fluorophenyl)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP-compliant manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider refrigeration (2-8°C).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.