Description

Acetaminophen-13C2, 15N1 is a stable isotope-labeled analog of the common analgesic and antipyretic drug, acetaminophen. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise quantification of acetaminophen in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of acetaminophen in plasma, serum, urine, and tissue samples.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in both preclinical and clinical research settings.
• Pharmaceutical Quality Control: Used in the development and validation of robust analytical methods for assay and impurity profiling of acetaminophen in drug substances and finished dosage forms.
• Forensic and Clinical Toxicology: Facilitates the accurate identification and quantification of acetaminophen in cases of overdose or therapeutic drug monitoring.
• Method Development and Validation: Provides a stable, non-interfering isotopic standard to establish specificity, linearity, and accuracy in new analytical procedures.
• Environmental Analysis: Can be employed as a tracer in studies investigating the environmental fate and transport of pharmaceutical compounds.

Basic Information

Product Name	Acetaminophen-13C2, 15N1
CAS No.	360769-21-7
Molecular Formula	C813C2H915NO2
Molecular Weight	154.14 g/mol (approximate)
Synonyms	Paracetamol-13C2,15N; 4'-Hydroxyacetanilide-13C2,15N; APAP-13C2,15N; N-(4-Hydroxyphenyl)acetamide-13C2,15N; 4-Acetamidophenol-13C2,15N; Isotopically Labeled Acetaminophen; [13C2,15N]-Acetaminophen; Stable Isotope-Labeled Paracetamol
EINECS	Contact for details

Quality Control

Every batch of Acetaminophen-13C2, 15N1 is manufactured and analyzed under strict quality protocols to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (HPLC)	≥ 98.0%
Solubility	Soluble in methanol, ethanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.