Description

4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid is a specialized bifunctional linker molecule, combining a maleimide group with a hydrazide moiety in a cyclohexane scaffold. This compound is critical for creating stable, site-specific conjugations, particularly in bioconjugation chemistry where controlled linkage is paramount. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for antibody-drug conjugate (ADC) development, protein labeling, and advanced polymer synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein & Peptide Modification: Used for site-specific labeling of proteins, enzymes, and peptides via the maleimide-thiol reaction and hydrazide-carbonyl coupling.
• Surface Functionalization: Enables the immobilization of biomolecules onto chips, nanoparticles, or resins for biosensor and diagnostic assay development.
• Polymer & Material Science: Serves as a cross-linking agent or functional monomer for synthesizing smart hydrogels, drug delivery carriers, and functionalized polymers.
• Bioconjugation Reagent Kits: A core component in commercial kits designed for labeling and cross-linking applications in life science research.

Basic Information

Product Name	4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid
CAS No.	359436-59-2
Molecular Formula	C12H17N3O4 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	4-(Maleimidomethyl)cyclohexanecarboxylic acid hydrazide TFA salt; 4-(Maleimidomethyl)-1-cyclohexanecarboxylic acid hydrazide trifluoroacetate; 4-Maleimidomethyl-cyclohexanecarboxylic acid hydrazide TFA; MCCH-Hz TFA; (4-(Maleimidomethyl)cyclohexane-1-carbonyl)hydrazine;2,2,2-trifluoroacetic acid; ADC Linker intermediate; Maleimide-PEG4-acid hydrazide TFA salt analog
EINECS	Contact for details

Quality Control

Our 4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under anhydrous conditions. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.