Description

Dexamethasone-D5 CAS NO 358731-91-6 is a stable isotope-labeled analog of the potent synthetic glucocorticoid dexamethasone, where five hydrogen atoms are replaced by deuterium. This isotopic labeling is critical for enhancing the precision and reliability of quantitative mass spectrometry analysis in complex biological matrices. It is an essential reference standard and internal standard for researchers and quality control laboratories in the pharmaceutical and life sciences sectors requiring accurate pharmacokinetic, metabolic, and bioanalytical studies.

Application

• Used as an internal standard for the accurate quantification of dexamethasone in biological samples (e.g., plasma, serum, urine) via LC-MS/MS and GC-MS.
• Serves as a certified reference material (CRM) for method development, validation, and quality control in pharmaceutical analysis.
• Facilitates drug metabolism and pharmacokinetic (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• Enables precise therapeutic drug monitoring (TDM) in clinical research and toxicology.
• Applied in isotope dilution mass spectrometry techniques to achieve high analytical accuracy and compensate for matrix effects and instrument variability.
• Supports research in anti-inflammatory and immunosuppressant mechanism studies where tracking the parent compound is required.

Basic Information

Product Name	Dexamethasone-D5
CAS No.	358731-91-6
Molecular Formula	C22H24D5FO5
Molecular Weight	397.48 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione-16,16,17,21,21-d5; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-16,16,17,21,21-d5; Dexamethasone (16,16,17,21,21-d5); Deuterated Dexamethasone; Dexamethasone-d5; [16,16,17,21,21-2H5]-Dexamethasone
EINECS	Contact for details

Quality Control

Our Dexamethasone-D5 is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, MS for isotopic enrichment verification, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all test results, including purity, isotopic purity, and residual solvent analysis, are provided and traceable to the specific production lot.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.