Description

4-Arm Pegn-Mal 2K, 5K, 10K, 20K is a multi-arm, maleimide-terminated polyethylene glycol (PEG) derivative, a crucial building block for advanced bioconjugation and crosslinking. This product matters for its ability to create stable, multi-point linkages with thiol-containing molecules, enabling the development of sophisticated drug delivery systems, hydrogels, and diagnostic materials. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, high-purity functionalized PEGs for creating next-generation therapeutics and biomaterials.

Application

• Bioconjugation Platform: Site-specific conjugation of peptides, proteins, antibodies, and oligonucleotides via thiol-maleimide chemistry for ADC (Antibody-Drug Conjugate) and protein-polymer conjugate development.
• Hydrogel Formation: Crosslinking agent for creating 3D network hydrogels with tunable mechanical properties for tissue engineering, wound healing, and 3D cell culture scaffolds.
• Drug Delivery Systems: Core component for constructing multi-arm PEG-based micelles, dendrimers, and nanoparticles for controlled and targeted drug release.
• Surface Functionalization: Modification of gold nanoparticles, quantum dots, and other surfaces to introduce biocompatible PEG layers and reactive handles for further coupling.
• Diagnostic Reagents: Used in the synthesis of multi-valent diagnostic probes and contrast agents for enhanced signal and specificity in imaging assays.
• Biomaterial Modification: PEGylation of biomaterials to reduce immunogenicity, prevent non-specific protein adsorption, and improve biocompatibility.

Basic Information

Product Name	4-Arm Pegn-Mal 2K, 5K, 10K, 20K
CAS No.	357277-62-4
Molecular Formula	CnH2n+2On+1 (Variable based on PEG chain length 'n')
Molecular Weight	2,000; 5,000; 10,000; 20,000 g/mol (nominal)
Synonyms	4-Arm PEG Maleimide; Tetra-Arm PEG-MAL; 4-Arm Polyethylene Glycol Maleimide; 4-Arm PEG-Mal; Maleimide-PEG4-tetraol; Tetrakis-maleimide terminated PEG; Multi-arm PEG Maleimide; Star-PEG Maleimide; 4-Arm PEG-(OMe)4-Maleimide
EINECS	Contact for details

Quality Control

Our 4-Arm Pegn-Mal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H and 13C) for structural confirmation, GPC/SEC for molecular weight distribution (PDI), and HPLC to quantify purity and maleimide functionality. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) for long-term stability. This product is hygroscopic (moisture-sensitive). For short-term use, it may be stored at 2-8°C for up to one month. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the maleimide group.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies with structure
Molecular Weight (Nominal)	2,000; 5,000; 10,000; 20,000 Da
Purity (HPLC)	≥ 95%
Maleimide Functionality	≥ 3.8 groups / molecule
Polydispersity Index (PDI, GPC)	≤ 1.05 (for 2K), ≤ 1.10 (for 5K, 10K, 20K)
Moisture Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF, Methylene Chloride

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.