Description

α-(Trifluoromethyl)Ethenyl Boronic Acid is a specialized organoboron reagent featuring a reactive vinyl group and a trifluoromethyl substituent. This compound is highly valued for its role as a key building block in modern synthetic chemistry, particularly in cross-coupling reactions to introduce the valuable trifluoromethylvinyl moiety. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require advanced intermediates for the development of novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those incorporating trifluoromethyl groups to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced materials with unique surface properties.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic acid partner for palladium-catalyzed coupling with various aryl or vinyl halides, enabling efficient carbon-carbon bond formation.
• Fluorine Chemistry: An important reagent for introducing fluorine-containing motifs into complex molecules, a common strategy in modern drug discovery.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands and organometallic complexes for catalytic applications.

Basic Information

Product Name	α-(Trifluoromethyl)Ethenyl Boronic Acid
CAS No.	357274-85-2
Molecular Formula	C3H4BF3O2
Molecular Weight	139.87 g/mol
Synonyms	(2,2,2-Trifluoroethenyl)boronic acid; 2,2,2-Trifluorovinylboronic acid; (Trifluorovinyl)boronic acid; B-(2,2,2-Trifluoroethenyl)boronic acid; 1-Trifluoroethenylboronic acid; α-Trifluoromethylvinylboronic acid; TFVB; 357274-85-2
EINECS	Contact for details

Quality Control

Our α-(Trifluoromethyl)Ethenyl Boronic Acid is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.