Description

Rotigaptide is a selective gap junction modifier and antiarrhythmic peptide analog developed for cardiovascular research and therapeutic applications. This compound is significant for its role in modulating cardiac connexins to prevent arrhythmias and protect against ischemia-reperfusion injury. It is primarily needed by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on developing novel cardioprotective agents and investigating cellular communication pathways.

Application

• Cardiovascular Research: A key tool compound for studying gap junction modulation, cardiac electrophysiology, and arrhythmia mechanisms.
• Drug Discovery & Development: Serves as a reference standard and lead compound in preclinical programs targeting heart failure, atrial fibrillation, and myocardial infarction.
• Pharmacology Studies: Used to investigate the cardioprotective effects of connexin 43 modulation during ischemia-reperfusion injury.
• Biochemical Assays: Employed in in vitro and ex vivo models to assess compound efficacy and mechanism of action.
• Academic & Institutional Research: Fundamental research into intercellular communication, signal transduction, and cardiac tissue engineering.
• GMP Intermediate: Potential use as a high-purity chemical intermediate in the synthesis of advanced therapeutic candidates under controlled conditions.

Basic Information

Product Name	Rotigaptide
CAS No.	355151-12-1
Molecular Formula	C31H44N8O8
Molecular Weight	632.73 g/mol
Synonyms	ZP123; GAP-134; (2S)-2-[(2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-1-(diaminomethylideneamino)-4-methylpentan-2-yl]amino]-5-guanidino-5-oxopentanoic acid; Antiarrhythmic peptide analog; Gap junction modifier
EINECS	Contact for details

Quality Control

Our Rotigaptide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and GMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Single Impurity (HPLC)	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.