Description

(Carboxymethyloximino)Spiperone, Hemihydrate is a high-purity chemical derivative of the antipsychotic agent spiperone, modified with a carboxymethyloximino functional group. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development, particularly for the synthesis and study of novel dopamine receptor ligands. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on neuropharmacology, radiopharmaceutical development, and molecular imaging.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antipsychotic and neuropharmacological agents targeting dopamine receptors.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in receptor binding assays and pharmacological studies to investigate dopamine D2 receptor interactions and signaling pathways.
• Radiopharmaceutical Precursor: Serves as a precursor for the development of positron emission tomography (PET) tracers, such as [11C] or [18F] labeled analogs, for neuroimaging.
• Metabolite Studies: Utilized in the identification and characterization of spiperone metabolites during drug metabolism and pharmacokinetics (DMPK) research.

Basic Information

Product Name	(Carboxymethyloximino)Spiperone, Hemihydrate
CAS No.	355012-90-7
Molecular Formula	C24H30FN3O5 • ½H2O
Molecular Weight	Contact for details
Synonyms	8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 4-(Carboxymethyl)oxime hemihydrate; (Carboxymethyloximino)Spiperone; Spiperone Carboxymethyloxime; Spiperone Oxime Acetic Acid; Spiperone Derivative; Dopamine D2 Receptor Ligand Intermediate
EINECS	Contact for details

Quality Control

Our (Carboxymethyloximino)Spiperone, Hemihydrate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom synthesis to meet specific pharmacopeial or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	2.0% - 4.0% (Theoretical for hemihydrate)
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.