Description

Ac-Ala-Ser-Thr-Asp-Amc is a specialized fluorogenic peptide substrate designed for sensitive enzymatic assays. This compound is critical for researchers and developers in the life sciences sector, providing a reliable tool for studying protease activity and enzyme kinetics. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic biochemistry laboratories focused on proteolytic pathways.

Application

• Protease Activity Assays: As a fluorogenic substrate for monitoring and quantifying the activity of specific proteases in biochemical research.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize potential protease inhibitors.
• Enzyme Kinetic Studies: Essential for determining kinetic parameters (Km, Vmax) of target enzymes in purified systems.
• Diagnostic Development: Serves as a key component in the development of clinical diagnostic assays for diseases involving aberrant protease activity.
• Cell Biology Research: Employed to study intracellular proteolytic processes and signaling pathways within live cells.
• Quality Control in Biologics: Used to assess the presence and activity of proteases during the manufacturing and purification of therapeutic proteins.

Basic Information

Product Name	Ac-Ala-Ser-Thr-Asp-Amc
CAS No.	354151-60-3
Molecular Formula	C₂₄H₃₂N₆O₁₂
Molecular Weight	596.55 g/mol
Synonyms	Acetyl-Ala-Ser-Thr-Asp-7-Amino-4-methylcoumarin; Ac-ASTD-AMC; Ac-Ala-Ser-Thr-Asp-AMC; Acetyl-Alanyl-Seryl-Threonyl-Aspartic acid-AMC; Fluorogenic Peptide Substrate Ac-ASTD-AMC; Caspase Substrate Ac-ASTD-AMC; 7-Amino-4-methylcoumarin labeled peptide Ac-ASTD; N-Acetyl-L-alanyl-L-seryl-L-threonyl-L-aspartic acid 7-amido-4-methylcoumarin
EINECS	Contact for details

Quality Control

Our Ac-Ala-Ser-Thr-Asp-Amc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and MS for identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.