Description

n-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide is a high-purity, non-natural amino acid derivative featuring a unique azetidine ring structure. This compound serves as a critical advanced pharmaceutical intermediate and chiral building block for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Protease Inhibitor Synthesis: Used as a core building block in the construction of potential protease inhibitor candidates for virology and oncology research.
• Peptidomimetics Development: The azetidine scaffold is valuable for creating constrained peptide mimics to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Bioconjugation & Labeling: The reactive functional groups can be utilized for attaching probes or linkers in chemical biology applications.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective synthetic routes.

Basic Information

Product Name	n-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide
CAS No.	353249-19-1
Molecular Formula	C12H13N3O
Molecular Weight	215.25 g/mol
Synonyms	2-Azetidinecarboxamide, N-[(4-cyanophenyl)methyl]-, (2S)-; L-Azetidine-2-carboxylic acid (4-cyanobenzyl)amide; (S)-N-(4-Cyanobenzyl)azetidine-2-carboxamide; 353249-19-1; (2S)-N-[(4-Cyanophenyl)methyl]-2-azetidinecarboxamide; Azetidine-2-carboxamide, N-[(4-cyanophenyl)methyl]-, (S)-; (S)-Azetidine-2-carboxylic acid 4-cyanobenzylamide
EINECS	Contact for details

Quality Control

Our n-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, to ensure it meets the high standards required for pharmaceutical research. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.