Description

(R)-(6,6'-Dimethoxybiphenyl-2,2'-Diyl)Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphine] is a highly specialized, chiral monodentate phosphine ligand, a key building block in advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are critical for the efficient and sustainable synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their synthetic routes.

Application

• As a privileged ligand in asymmetric hydrogenation reactions for the synthesis of chiral amines, amino acids, and alcohols.
• Catalyst component for enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) in pharmaceutical intermediate manufacturing.
• Use in the development of homogeneous transition metal catalysts for academic and industrial research into new synthetic methodologies.
• Critical reagent for the asymmetric synthesis of active pharmaceutical ingredients (APIs) and natural products requiring high optical purity.
• Application in agrochemical research for the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Precursor for the synthesis of tailored chiral catalysts and immobilized catalyst systems for flow chemistry applications.

Basic Information

Product Name	(R)-(6,6'-Dimethoxybiphenyl-2,2'-Diyl)Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphine]
CAS No.	352655-61-9
Molecular Formula	C78H100O8P2
Molecular Weight	1219.55 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-DTBM-SegPhos; (R)-3,3',5,5'-Tetra-tert-butyl-2,2',4,4',6,6'-hexamethoxy-5,5'-bis(diphenylphosphino)-1,1'-biphenyl; (R)-DTBM-SEGPHOS ligand; (R)-DTBM-Segphos; (R)-DTBM-SEGPHOS (DTBM = 3,5-di-tert-butyl-4-methoxyphenyl); (R)-SEGPHOS derivative with DTBM substituents
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management systems. We ensure high chemical and chiral purity through advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, enantiomeric excess (ee), and other critical parameters to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.