Description

5-Chloro-2-Fluoro-3-Methylphenylboronic Acid is a high-purity, synthetically valuable boronic acid derivative. This compound matters as a critical building block in modern organic synthesis, particularly for the construction of complex molecules via cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the unique properties of the halogenated phenyl ring.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for the production of bespoke compounds and advanced intermediates on a commercial scale.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-Methylphenylboronic Acid
CAS No.	352535-87-6
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(5-Chloro-2-fluoro-3-methylphenyl)boronic acid; 3-Methyl-5-chloro-2-fluorophenylboronic acid; 5-Chloro-2-fluoro-m-tolylboronic acid; Boronic acid, B-(5-chloro-2-fluoro-3-methylphenyl)-; 352535-87-6; (5-Chloro-2-fluoro-3-methylphenyl)boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-3-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.