Description

2-Chloro-6-Fluoro-5-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in advanced materials science.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated and chlorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the specific halogen pattern is required for bioactivity.
• Material Science Research: Serves as a precursor for synthesizing functionalized polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a versatile boronic acid coupling partner with various aryl/vinyl halides to create biaryl and other conjugated systems.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated boronic acids.

Basic Information

Product Name	2-Chloro-6-Fluoro-5-Methylphenylboronic Acid
CAS No.	352535-86-5
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-6-fluoro-5-methylphenyl)boronic acid; 2-Chloro-6-fluoro-5-methylbenzeneboronic acid; Boronic acid, B-(2-chloro-6-fluoro-5-methylphenyl)-; 352535-86-5; 2-Chloro-6-fluoro-5-methyl-phenylboronic acid; 5-Methyl-2-chloro-6-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-5-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.