Description

2-Chloro-6-Fluoro-3-Methylphenylboronic Acid is a high-purity, synthetically valuable boronic acid derivative. This compound serves as a critical building block in modern organic synthesis, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex, multi-substituted biaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides that require specific halogenated phenyl motifs for enhanced bioactivity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics (OPVs).
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis and asymmetric synthesis.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Methylphenylboronic Acid
CAS No.	352535-85-4
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-6-fluoro-3-methylphenyl)boronic acid; 2-Chloro-6-fluoro-m-tolylboronic acid; 3-Methyl-2-chloro-6-fluorophenylboronic acid; Boronic acid, B-(2-chloro-6-fluoro-3-methylphenyl)-; 352535-85-4; 2-Chloro-6-fluoro-3-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluoro-3-Methylphenylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity and batch-to-batch consistency for your critical synthesis workflows. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.