Description

3-Chloro-2-Fluorophenylboronic Acid is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific halogenated biphenyl structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular structure is critical.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Fine Chemical Manufacturing: An essential reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-2-Fluorophenylboronic Acid
CAS No.	352535-82-1
Molecular Formula	C6H5BClFO2
Molecular Weight	173.37 g/mol
Synonyms	(3-Chloro-2-fluorophenyl)boronic acid; 2-Fluoro-3-chlorophenylboronic acid; Boronic acid, B-(3-chloro-2-fluorophenyl)-; 3-Chloro-2-fluorobenzeneboronic acid; (2-Fluoro-3-chlorophenyl)boronic acid; 3-Chloro-2-fluoro-benzeneboronic acid; CAS 352535-82-1
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every lot. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.