Description

4-Fluoro-3-Nitrophenylboronic Acid is a versatile and highly functionalized boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the nitro and fluoro substituents provide sites for further chemical elaboration. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic scaffolds.
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via polymerization or small-molecule synthesis.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of chemical probes and inhibitors targeting specific proteins.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between aromatic rings.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-Nitrophenylboronic Acid
CAS No.	352530-22-4
Molecular Formula	C6H5BFNO4
Molecular Weight	184.92 g/mol
Synonyms	(4-Fluoro-3-nitrophenyl)boronic acid; 3-Nitro-4-fluorobenzeneboronic acid; 4-Fluoro-3-nitrobenzeneboronic acid; B-(4-Fluoro-3-nitrophenyl)boronic acid; 352530-22-4; 4-Fluoro-3-nitro-phenylboronic acid; 4-Fluoro-3-nitrophenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Nitrophenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.