Description

Fmoc-L-2-Trifluoromethylphenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. Its core value lies in the strategic incorporation of a trifluoromethyl group onto the phenylalanine side chain, which significantly alters the physicochemical properties of the resulting peptides, enhancing metabolic stability and lipophilicity. This building block is essential for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on developing novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide analogs with improved pharmacokinetic profiles, such as enhanced membrane permeability and resistance to enzymatic degradation.
• Chemical Biology Probes: Incorporation into peptides to study protein-protein interactions, enzyme mechanisms, and cellular processes via the unique properties of the fluorine label.
• Peptidomimetic Development: Serves as a key scaffold for creating non-natural peptide structures that mimic natural bioactive peptides.
• Pharmaceutical Intermediate: A building block in the synthesis of active pharmaceutical ingredients (APIs) for candidate drugs.
• Research & Development: Fundamental reagent in academic and industrial labs exploring structure-activity relationships (SAR) in peptide science.

Basic Information

Product Name	Fmoc-L-2-Trifluoromethylphenylalanine
CAS No.	352523-16-1
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-2-(Trifluoromethyl)-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(trifluoromethyl)-L-phenylalanine; Fmoc-L-2-CF3-Phe-OH; Fmoc-2-Tfm-Phe-OH; (2S)-3-[2-(Trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid; N-α-Fmoc-2-(trifluoromethyl)-L-phenylalanine; Fmoc-(2-CF3)Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Trifluoromethylphenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.