Description

Sodium Dehydroepiandrosterone-16,16-D2 Sulfate is a high-purity, deuterium-labeled derivative of the endogenous steroid hormone DHEA sulfate. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for pharmacokinetic studies, hormone level monitoring, and the development of novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of endogenous DHEA-S in biological matrices (e.g., serum, plasma) in clinical and research settings.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies for drugs targeting steroid pathways.
• Clinical Diagnostics: Enables accurate calibration and quality control in hormone assay kits and laboratory-developed tests (LDTs).
• Endocrinology Studies: Facilitates research into adrenal function, aging, and disorders related to androgen metabolism.
• Forensic Toxicology: Supports the analysis of steroid profiles in anti-doping control and forensic investigations.
• Biomarker Discovery & Validation: Aids in the development and validation of steroid biomarkers for various disease states.

Basic Information

Product Name	Sodium Dehydroepiandrosterone-16,16-D2 Sulfate
CAS No.	352431-52-8
Molecular Formula	C19H25D2NaO4S
Molecular Weight	374.48 g/mol (approx.)
Synonyms	Sodium DHEA-16,16-D2 Sulfate; DHEA-S-d2 Sodium Salt; 3β-Hydroxy-5-androsten-17-one 3-sulfate-16,16-D2 Sodium Salt; Dehydroisoandrosterone Sulfate-16,16-D2 Sodium Salt; Prasterone Sulfate-d2 Sodium Salt; Androstenolone Sulfate-d2 Sodium Salt; 5-Androsten-3β-ol-17-one 3-sulfate-16,16-D2 Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Sodium Dehydroepiandrosterone-16,16-D2 Sulfate CAS 352431-52-8 is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to certified reference materials where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.