Description

Triamcinolone-6-D1 Acetonide-D6 is a high-purity, multi-deuterated analog of the synthetic glucocorticoid Triamcinolone Acetonide, specifically designed for use as an internal standard in quantitative mass spectrometry. This stable isotope-labeled compound is essential for ensuring analytical accuracy and reliability in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS methods for the precise quantification of Triamcinolone Acetonide and related metabolites in plasma, serum, and tissue samples.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development and Validation: Used to establish and validate robust, sensitive, and specific analytical methods in compliance with GLP and FDA/EMA guidelines.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites.
• Doping Control Analysis: Supports the detection and confirmation of prohibited glucocorticoids in sports anti-doping programs.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and assay verification of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Triamcinolone-6-D1 Acetonide-D6
CAS No.	352431-33-5
Molecular Formula	C24H25D7FO6
Molecular Weight	440.53 g/mol
Synonyms	9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide-6,21,21,21,21,21,21-d7; Triamcinolone Acetonide-d7; 9α-Fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione-6,21,21,21,21,21,21-d7; Triamcinolone-16,17-acetonide-d7; Deuterated Triamcinolone Acetonide; [6,21,21,21,21,21,21-d7]-Triamcinolone Acetonide
EINECS	Contact for details

Quality Control

Every batch of Triamcinolone-6-D1 Acetonide-D6 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity (by HPLC), and spectroscopic confirmation (NMR, MS) is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a desiccator under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Isotopic Enrichment (MS)	≥ 99.0% (d7)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.