Description

Azetidine, 1-[[(2S,4R)-4-Hydroxy-2-Pyrrolidinyl]Carbonyl]- (9Ci) is a high-purity chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex, stereochemically defined targets such as protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the construction of complex molecular scaffolds for drug discovery.
• Asymmetric Synthesis: Serves as a valuable precursor in catalytic and stoichiometric asymmetric transformations to introduce the azetidine-pyrrolidine motif.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and pharmacological studies due to its functional handles.
• Peptidomimetics: Integral for designing and synthesizing peptidomimetic compounds that mimic natural peptides but with enhanced stability and bioavailability.

Basic Information

Product Name	Azetidine, 1-[[(2S,4R)-4-Hydroxy-2-Pyrrolidinyl]Carbonyl]- (9Ci)
CAS No.	352278-25-2
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	1-[(2S,4R)-4-Hydroxypyrrolidine-2-carbonyl]azetidine; (2S,4R)-1-(Azetidine-1-carbonyl)-4-hydroxypyrrolidine-2-carbonitrile (related nitrile); 4-Hydroxy-L-proline azetidine amide; Azetidine-1-carboxylic acid, (4R)-4-hydroxy-L-prolyl-; (2S,4R)-N-(Azetidin-1-yl)-4-hydroxypyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Azetidine, 1-[[(2S,4R)-4-Hydroxy-2-Pyrrolidinyl]Carbonyl]- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.