Description

N5-[(Phenylmethoxy)Carbonyl]-D-Ornithine Methyl Ester is a protected derivative of the non-proteinogenic amino acid D-ornithine, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptides and peptidomimetics, particularly for pharmaceutical research and development. This high-purity intermediate is essential for medicinal chemists and process development scientists working on novel therapeutic agents, including enzyme inhibitors and bioactive peptides.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-ornithine residues with orthogonal protecting groups.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Critical building block in academic and industrial R&D for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules in pilot plants and manufacturing.

Basic Information

Product Name	N5-[(Phenylmethoxy)Carbonyl]-D-Ornithine Methyl Ester
CAS No.	352274-96-5
Molecular Formula	C14H20N2O4
Molecular Weight	280.32 g/mol
Synonyms	D-Ornithine, N5-[(benzyloxy)carbonyl]-, methyl ester; Z-D-Orn-OMe; (R)-Methyl 5-(((benzyloxy)carbonyl)amino)-2-aminopentanoate; Nα-Cbz-D-ornithine methyl ester; Cbz-D-Ornithine-OMe; Methyl N5-carbobenzoxy-D-ornithinate; N5-Carbobenzoxy-D-ornithine methyl ester
EINECS	Contact for details

Quality Control

Our N5-[(Phenylmethoxy)Carbonyl]-D-Ornithine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.