Description

Separase CAS NO 351527-77-0 is a highly specific and potent protease enzyme inhibitor, widely recognized for its critical role in biochemical and cell biology research. This compound is essential for studying cell cycle regulation, particularly the separation of sister chromatids during anaphase. It is a vital tool for researchers and pharmaceutical developers in the fields of oncology, neurobiology, and fundamental molecular biology, enabling precise experimental control over proteolytic activity.

Application

• Cell Biology Research: Used to inhibit Separase activity in studies of chromosome segregation, anaphase initiation, and cell cycle progression.
• Oncology & Cancer Research: Employed as a research tool to investigate mechanisms of genomic instability and to develop potential therapeutic strategies targeting cell division.
• Neurobiology Studies: Applied in research exploring neuronal development, function, and diseases related to cell cycle dysregulation.
• Biochemical Assay Development: Serves as a key reference standard and inhibitor in enzymatic assays to characterize Separase function and screen for novel modulators.
• Pharmaceutical R&D: Utilized in drug discovery pipelines to validate Separase as a target and to evaluate the efficacy of candidate therapeutic compounds.

Basic Information

Product Name	Separase
CAS No.	351527-77-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Separase Inhibitor; Sepin-1; ESPL1 Inhibitor; (S)-2-((S)-5-(4-Chlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-N-(3,3-dimethylbutyl)pentanamide; CAS 351527-77-0; Sepin 1; Separase inhibitor Sepin-1
EINECS	Contact for details

Quality Control

Our Separase is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including purity verification by HPLC and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.