Description

[2-(Aminocarbonyl)Ethyl] Methanethiosulfonate is a specialized organosulfur compound featuring a reactive methanethiosulfonate group linked to a carbamoylethyl moiety. This unique bifunctional structure makes it a valuable reagent for site-specific protein modification and bioconjugation, particularly in the development of antibody-drug conjugates (ADCs) and other therapeutic biologics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require precise and stable covalent linkages for drug targeting, diagnostic probe development, and advanced material science.

Application

• Bioconjugation Reagent: Primary use for site-specific modification of cysteine residues in proteins, antibodies, and peptides.
• Antibody-Drug Conjugate (ADC) Development: A key building block for creating stable, homogeneous linker-payload constructs for targeted cancer therapies.
• Proteomics Research: Used in chemical proteomics for labeling, enrichment, and identification of proteins of interest.
• Diagnostic Assay Development: Enables the stable attachment of fluorophores, enzymes, or other detection tags to biomolecules for immunoassays and biosensors.
• Polymer and Material Science: Serves as a functional monomer or cross-linker for synthesizing smart polymers and hydrogels with tailored biological properties.
• Chemical Biology Tool: Facilitates the study of protein function, structure, and interactions through controlled chemical labeling.

Basic Information

Product Name	[2-(Aminocarbonyl)Ethyl] Methanethiosulfonate
CAS No.	351422-28-1
Molecular Formula	C4H9NO3S2
Molecular Weight	183.25 g/mol
Synonyms	2-(Methanesulfonylsulfanylcarbonylamino)ethyl methanethiosulfonate; N-(2-Methanethiosulfonatoethyl)acetamide (common misnomer); Acetamide, N-[2-[(methylsulfonyl)thio]ethyl]-; MTSEA-acetamide derivative; Carbamoylethyl MTS; 2-(Methanethiosulfonyl)ethylcarboxamide; S-(2-Carbamoylethyl) methanethiosulfonate; Protein modification reagent 351422-28-1
EINECS	Contact for details

Quality Control

Our [2-(Aminocarbonyl)Ethyl] Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay	≥ 97.0% (by titration/NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.