Description

n-Fmoc-4-Piperidinol CAS NO 351184-42-4 is a high-purity, protected piperidine derivative widely used as a critical building block in organic synthesis and pharmaceutical research. This compound is essential for the controlled introduction of the 4-hydroxypiperidine moiety, a privileged scaffold in medicinal chemistry, under Fmoc-protection strategies. It is primarily utilized by research scientists and process chemists in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Peptide Chemistry: Serves as a protected amino alcohol component in solid-phase peptide synthesis (SPPS) for constructing conformationally constrained peptides.
• Chemical Biology Probes: Used in the development of molecular probes and labeled compounds for studying biological pathways and enzyme function.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Combinatorial Library Synthesis: A valuable building block for generating diverse compound libraries in high-throughput screening and drug discovery programs.
• Academic and Industrial R&D: Fundamental research reagent in universities and corporate R&D laboratories for exploring new synthetic methodologies.

Basic Information

Product Name	n-Fmoc-4-Piperidinol
CAS No.	351184-42-4
Molecular Formula	C₂₀H₂₁NO₃
Molecular Weight	323.39 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-piperidinol; 4-Hydroxy-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine; 1-Fmoc-4-hydroxypiperidine; 4-Piperidinol, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-; 1-N-Fmoc-4-piperidinol; Fmoc-4-piperidinol; 4-Hydroxy-N-Fmoc-piperidine; 1-(9-Fluorenylmethyloxycarbonyl)-4-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Piperidinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.