Description

Boc- -(2-Chlorbenzyl)-Dl-Pro-Oh is a protected amino acid derivative, specifically a proline analog featuring a tert-butoxycarbonyl (Boc) protecting group and a 2-chlorobenzyl side chain. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering researchers precise control over molecular structure and stereochemistry. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly in oncology and metabolic disease research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of modified proline residues into peptide chains.
• Peptidomimetic Design: Essential for creating non-natural peptide analogs (peptidomimetics) with enhanced stability, bioavailability, and target specificity.
• Chemical Biology Research: Employed as a tool compound in studying enzyme-substrate interactions, protein folding, and receptor-ligand binding mechanisms.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and biochemistry.
• Scale-up & Process Chemistry: Suitable for process development and scale-up from milligram to kilogram quantities under GMP or non-GMP conditions.

Basic Information

Product Name	Boc- -(2-Chlorbenzyl)-Dl-Pro-Oh
CAS No.	351002-86-3
Molecular Formula	C₁₇H₂₂ClNO₄
Molecular Weight	339.82 g/mol
Synonyms	Boc-2-Chlorobenzyl-DL-proline; (RS)-1-[(2-Chlorophenyl)methyl]-2-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (RS)-1-[(2-chlorophenyl)methyl]pyrrolidine-2-carboxylate; DL-Proline, 1-[(2-chlorophenyl)methyl]-, 1,1-dimethylethyl ester; Boc-DL-Pro(2-Cl-Bzl)-OH; N-Boc-1-(2-Chlorobenzyl)-DL-proline; N-tert-Butoxycarbonyl-1-(2-chlorobenzyl)-DL-proline
EINECS	Contact for details

Quality Control

Our Boc- -(2-Chlorbenzyl)-Dl-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	DL-mixture (Racemic)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.