Description

Boc- -(4-Fluorbenzyl)-Dl-Pro-Oh CAS NO 351002-78-3 is a protected amino acid derivative, specifically a proline analog featuring a Boc (tert-butoxycarbonyl) protecting group and a 4-fluorobenzyl side chain. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering researchers precise control over molecular structure and function. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide-based drugs.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) for constructing custom peptide sequences.
• Chemical Biology Research: Used in the study of protein-protein interactions, enzyme mechanisms, and the development of molecular probes and diagnostics.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of lead compounds.
• Fine Chemical Production: Integrated into multi-step synthetic routes for the commercial-scale manufacture of specialty chemicals and advanced materials.

Basic Information

Product Name	Boc- -(4-Fluorbenzyl)-Dl-Pro-Oh
CAS No.	351002-78-3
Molecular Formula	C₁₇H₂₂FNO₄
Molecular Weight	323.36 g/mol
Synonyms	N-Boc-4-(4-Fluorobenzyl)-DL-proline; tert-Butyl 4-[(4-fluorophenyl)methyl]-2,5-dihydro-1H-pyrrole-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(4-fluorophenyl)methyl]-DL-proline; Boc-4-(4-Fluorobenzyl)-DL-proline; N-tert-Butoxycarbonyl-4-(4-fluorobenzyl)-DL-proline; 4-(4-Fluorobenzyl)-DL-proline N-Boc derivative
EINECS	Contact for details

Quality Control

Every batch of Boc- -(4-Fluorbenzyl)-Dl-Pro-Oh is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.