Description

Boc- -(1-Naphthylmethyl)-Dl-Pro-Oh is a protected amino acid derivative featuring a tert-butoxycarbonyl (Boc) group and a 1-naphthylmethyl side chain. This compound is a critical chiral building block and intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a proline derivative with a bulky, aromatic protecting group.
• Medicinal Chemistry Research: Serves as a building block for creating compound libraries to screen for biological activity in drug discovery programs.
• Bioconjugation: Can be employed in the design and synthesis of peptide conjugates for targeted drug delivery systems.
• Chemical Biology Probes: Useful in the synthesis of modified peptides used as probes to study enzyme function and protein-protein interactions.
• Academic Research: A valuable reagent for universities and research institutes studying peptide chemistry, asymmetric synthesis, and molecular recognition.

Basic Information

Product Name	Boc- -(1-Naphthylmethyl)-Dl-Pro-Oh
CAS No.	351002-65-8
Molecular Formula	C₂₁H₂₇NO₄
Molecular Weight	357.45 g/mol
Synonyms	Boc-1-Naphthylmethyl-DL-proline; N-(tert-Butoxycarbonyl)-1-(naphthalen-1-ylmethyl)-DL-proline; 1-[(1-Naphthyl)methyl]-N-Boc-DL-proline; tert-Butyl 1-(naphthalen-1-ylmethyl)-DL-prolinate-2-carboxylate; N-Boc-1-(1-Naphthylmethyl)-DL-proline; DL-Proline, 1-[(1-naphthalenyl)methyl]-, 1-(1,1-dimethylethyl) ester; Boc-DL-Pro(1-Naphthylmethyl)-OH
EINECS	Contact for details

Quality Control

Our Boc- -(1-Naphthylmethyl)-Dl-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.