Description

Estrone-2,4-D2 CAS NO 350820-16-5 is a deuterium-labeled analog of the natural estrogen hormone estrone, specifically deuterated at the 2 and 4 positions of the aromatic ring. This isotopic labeling makes it an indispensable internal standard for the precise and accurate quantification of estrone in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by research institutions, pharmaceutical companies, and clinical diagnostic laboratories engaged in steroid hormone analysis, endocrine research, and bioanalytical method development.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical internal standard for the quantification of endogenous estrone in bioanalytical assays, ensuring high accuracy and correcting for matrix effects and instrument variability.
• Endocrine and Metabolic Research: Used in studies investigating estrogen biosynthesis, metabolism, and their role in physiological and pathological processes.
• Clinical Diagnostics: Employed in the development and validation of high-sensitivity tests for hormone level monitoring in patient serum, plasma, or urine.
• Pharmaceutical Development: Applied in pharmacokinetic and pharmacodynamic studies of estrogen-based therapies and in drug metabolism investigations.
• Doping Control Analysis: Utilized in sports anti-doping laboratories for the definitive identification and quantification of prohibited endogenous steroids.
• Environmental Analysis: Aids in tracing and quantifying natural and synthetic estrogens in environmental samples.

Basic Information

Item	Details
Product Name	Estrone-2,4-D2
CAS No.	350820-16-5
Molecular Formula	C18H20D2O2
Molecular Weight	272.39 g/mol
Synonyms	Estrone-2,4-d2; 3-Hydroxyestra-1,3,5(10)-trien-17-one-2,4-d2; [2,4-Dideutero]estrone; E1-2,4-D2; Deuterated Estrone (2,4-); Estra-1,3,5(10)-trien-3-ol-17-one-2,4-d2; 2,4-Dideutero-17-oxoestra-1,3,5(10)-trien-3-ol
EINECS	Contact for details

Quality Control

Our Estrone-2,4-D2 is produced and handled under strict quality protocols to ensure the isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized using NMR and high-resolution mass spectrometry to confirm deuteration level and chemical identity. Purity is verified by HPLC. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D (2,4-positions)
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.