Description

Norbuprenorphine-D3 is a stable isotope-labeled analog of norbuprenorphine, a primary metabolite of the opioid medication buprenorphine. This deuterated compound is an essential reference standard for ensuring accurate and reliable analytical results in forensic, clinical, and pharmaceutical research. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical quality control departments engaged in drug metabolism studies, toxicology screening, and method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise analysis of norbuprenorphine and buprenorphine in biological matrices.
• Forensic Toxicology: Used in the development and validation of analytical methods for detecting and quantifying opioid use in urine, blood, and hair samples.
• Clinical Research & Pharmacokinetics: Enables accurate tracking of buprenorphine metabolism and elimination in human clinical trials and drug interaction studies.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of buprenorphine-based pharmaceutical products.
• Method Development & Validation: Provides a stable, non-interfering standard for establishing specificity, accuracy, and precision in new analytical procedures.
• Reference Material for Certified Standards: Acts as a high-purity starting material for the preparation of certified reference materials (CRMs) and calibration solutions.

Basic Information

Product Name	Norbuprenorphine-D3
CAS No.	350482-19-8
Molecular Formula	C₂₅H₃₀D₃NO₄
Molecular Weight	416.56 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-6β-[(2S)-2-hydroxy-3,3,3-trideuterio-3-phenylpropyl]morphinan-7-one; 6β-(2-Hydroxy-3,3,3-trideuterio-3-phenylpropyl)-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-17-(cyclopropylmethyl)morphinan-7-one; Deuterated Norbuprenorphine; Nor-buprenorphine-d3; Norbuprenorphine D3; Norbuprenorphine (D3)
EINECS	Contact for details

Quality Control

Our Norbuprenorphine-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity suitable for use as a reference standard. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.