Description

(D-Cys6,Asn7,D-Ala11,Cys14)-Bombesin (6-14) CAS NO 349657-39-2 is a synthetic, modified peptide fragment of the neuropeptide bombesin, designed for enhanced stability and specific receptor binding affinity. This compound is a critical research tool for studying the role of bombesin receptors (BB1, BB2, BB3) in various physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on oncology, neurology, and metabolic disorders.

Application

• Biomedical Research: Used as a receptor agonist/antagonist in studies of cancer cell proliferation, particularly in lung, prostate, and gastrointestinal cancers.
• Drug Discovery & Development: Serves as a key reference standard and pharmacophore model for designing novel therapeutics targeting bombesin receptors.
• Diagnostic Agent Development: Employed in the research and development of radiolabeled (e.g., with 68Ga, 177Lu) imaging probes for positron emission tomography (PET) and targeted radiotherapy.
• Neuroscience Studies: Investigates the role of bombesin-like peptides in central nervous system functions, including stress response, feeding behavior, and thermoregulation.
• In Vitro Assays: Acts as a critical component in cell-based assays, receptor binding studies, and signal transduction pathway analysis.
• Peptide Chemistry & Stability Studies: The D-amino acid substitutions make it a valuable subject for studying peptide stability, degradation resistance, and structure-activity relationships (SAR).

Basic Information

Product Name	(D-Cys6,Asn7,D-Ala11,Cys14)-Bombesin (6-14)
CAS No.	349657-39-2
Molecular Formula	C44H66N14O13S2
Molecular Weight	1063.2 g/mol
Synonyms	Bombesin (6-14), D-Cys-Asn-D-Ala-Cys analog; [D-Cys6, Asn7, D-Ala11, Cys14]-Bombesin(6-14); Bombesin fragment 6-14 analog; Modified Bombesin (6-14) peptide; BBN(6-14) analog; GRP(18-26) analog (partial sequence); Receptor-specific bombesin analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of (D-Cys6,Asn7,D-Ala11,Cys14)-Bombesin (6-14) undergoes comprehensive testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from multiple orthogonal analytical methods such as HPLC, MS, and amino acid analysis. Our quality commitment aligns with standards applicable to research-grade bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the peptide desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water, dilute acetic acid; slightly soluble in DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.