Description

n-(2-(Trifluoromethyl)Phenyl)-3-Chloropropanamide is a specialized organic intermediate featuring a trifluoromethylphenyl group and a chloropropanamide moiety. This compound is valued for its role in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of fluorine atoms and specific amide linkages is critical. It serves as a key building block for medicinal chemists and process development scientists working on novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders or inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, or insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, or organic electronic materials that require specific fluorinated aromatic components.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function or protein-ligand interactions in biochemical pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule libraries.

Basic Information

Product Name	n-(2-(Trifluoromethyl)Phenyl)-3-Chloropropanamide
CAS No.	349097-65-0
Molecular Formula	C10H9ClF3NO
Molecular Weight	251.63 g/mol
Synonyms	3-Chloro-N-[2-(trifluoromethyl)phenyl]propanamide; 1-(2-Trifluoromethylphenylamino)-3-chloropropan-1-one; 3-Chloro-N-(2-trifluoromethylphenyl)propanamide; 349097-65-0; Propanamide, 3-chloro-N-[2-(trifluoromethyl)phenyl]-; α-Chloro-β-oxo-2'-(trifluoromethyl)propionanilide
EINECS	Contact for details

Quality Control

Our n-(2-(Trifluoromethyl)Phenyl)-3-Chloropropanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from techniques such as HPLC, NMR, and GC-MS. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.