Description

Benzyl (S)-1-tert-Butylpyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in neurological and psychiatric therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecular architectures where the specific (S)-configuration of the pyrrolidine ring is essential for biological activity and drug efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent pharmaceutical compounds, including kinase inhibitors and neuromodulators.
• Asymmetric Synthesis: Used as a precursor or auxiliary in stereoselective reactions to introduce the (S)-1-tert-butylpyrrolidin-3-yl moiety into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: A potential building block for the development of inhibitors targeting specific enzymatic pathways.
• Chemical Biology Probes: Utilized in the creation of labeled or tagged compounds for investigating biological mechanisms and target engagement.

Basic Information

Product Name	Benzyl (S)-1-tert-Butylpyrrolidin-3-Ylcarbamate
CAS No.	348165-29-7
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	(S)-1-(tert-Butyl)-3-((benzyloxy)carbonylamino)pyrrolidine; Benzyl N-[(3S)-1-tert-butylpyrrolidin-3-yl]carbamate; Carbamic acid, N-[(3S)-1-(1,1-dimethylethyl)-3-pyrrolidinyl]-, phenylmethyl ester; (S)-1-Boc-3-(Cbz-amino)pyrrolidine (common abbreviation); (S)-3-(Benzyloxycarbonylamino)-1-tert-butylpyrrolidine; (S)-N-Cbz-3-amino-1-Boc-pyrrolidine; (S)-1-tert-Butyl-3-(Cbz-amino)pyrrolidine
EINECS	Contact for details

Quality Control

Our Benzyl (S)-1-tert-Butylpyrrolidin-3-Ylcarbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. We provide comprehensive analytical data including chiral purity verification. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.