Description

Thymidine-A,A,A,6-D4 CAS NO 347841-67-2 is a deuterium-labeled isotopologue of the nucleoside thymidine, where four hydrogen atoms are replaced with deuterium at specific positions. This high-purity labeled compound is essential for advanced research requiring precise tracking and quantification in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry, metabolic pathway studies, and the development of labeled drug standards.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of natural thymidine and related metabolites in bioanalytical assays.
• Metabolic Flux Analysis: Used as a stable isotope tracer to investigate nucleotide metabolism, DNA synthesis rates, and cellular proliferation pathways in research.
• Pharmaceutical R&D: Employed in the synthesis and pharmacokinetic studies of deuterated drug candidates, leveraging the kinetic isotope effect.
• Biomarker Discovery: Facilitates precise measurement of nucleoside turnover in studies aimed at identifying disease biomarkers.
• Nucleic Acid Research: A key reagent for studying DNA replication and repair mechanisms using isotope-labeled precursors.
• Quality Control Reference: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Product Name	Thymidine-A,A,A,6-D4
CAS No.	347841-67-2
Molecular Formula	C10H10D4N2O5
Molecular Weight	246.25 g/mol (approx.)
Synonyms	1-(2-Deoxy-β-D-ribofuranosyl)-5-methyl-[A,A,A,6-2H4]uracil; [A,A,A,6-2H4]Thymidine; Thymidine-d4; Deuterated Thymidine; 2'-Deoxy-5-methyluridine-d4; 5-Methyl-2'-deoxyuridine-d4; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione-d4
EINECS	Contact for details

Quality Control

Our Thymidine-A,A,A,6-D4 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and absence of critical impurities. We support research and production needs requiring compliance with various pharmacopeial standards, and specifications can be tailored upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.