Description

1-Bromo-2-Chloro-4-Difluoromethoxybenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides versatile reactivity for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluoromethoxy and halogenated benzene motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the synthesis of specialty monomers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of chemical space.
• Fluorine Chemistry: A valuable starting material for further fluorination or functionalization studies in medicinal and discovery chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-Bromo-2-Chloro-4-Difluoromethoxybenzene
CAS No.	345226-22-4
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	2-Chloro-1-bromo-4-(difluoromethoxy)benzene; 4-Bromo-3-chloro-1-(difluoromethoxy)benzene; Benzene, 1-bromo-2-chloro-4-(difluoromethoxy)-; 1-Bromo-2-chloro-4-(difluoromethoxy)benzene; 345226-22-4; 4-(Difluoromethoxy)-1-bromo-2-chlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-4-Difluoromethoxybenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal quality standards. Our quality commitment supports applications requiring GMP-grade starting materials and ensures reliable performance in critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.