Description

2,4-Bis-(Trifluoromethyl)Thiazole-5-Carboxylic Acid Ethyl Ester is a high-value fluorinated heterocyclic building block, essential for introducing the trifluoromethylthiazole moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced agrochemicals and pharmaceuticals with enhanced biological activity and metabolic stability. This compound is particularly sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Serves as a critical precursor for next-generation herbicides, fungicides, and insecticides, where the CF3-substituted thiazole ring improves efficacy and environmental profile.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and electronic materials that require fluorinated heterocyclic components for specific properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, hydrolysis to the corresponding acid, or further functionalization to create diverse chemical libraries for screening.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the outsourced R&D and scale-up activities of global life science companies.

Basic Information

Product Name	2,4-Bis-(Trifluoromethyl)Thiazole-5-Carboxylic Acid Ethyl Ester
CAS No.	344744-09-8
Molecular Formula	C9H5F6NO2S
Molecular Weight	305.20 g/mol
Synonyms	Ethyl 2,4-Bis(trifluoromethyl)-1,3-thiazole-5-carboxylate; 5-Carbethoxy-2,4-bis(trifluoromethyl)thiazole; 2,4-Bis(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester; 1,3-Thiazole-5-carboxylic acid, 2,4-bis(trifluoromethyl)-, ethyl ester; Ethyl 2,4-bis(trifluoromethyl)thiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 2,4-Bis-(Trifluoromethyl)Thiazole-5-Carboxylic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.