Description

n-Tau-Methyl-D3-Histamine 2Hcl is a stable isotope-labeled analog of histamine, specifically deuterated at the methyl group on the tau-nitrogen. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring accuracy and precision in mass spectrometry-based assays. It is primarily needed by pharmaceutical research organizations, contract research laboratories (CROs), and academic institutions engaged in pharmacokinetic studies, biomarker discovery, and metabolic pathway analysis.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate LC-MS/MS quantification of histamine and its metabolites in biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug effects on histamine pathways in preclinical and clinical research settings.
• Metabolomics Research: Used in targeted metabolomics to study the role of histamine in various disease states and physiological processes.
• Method Development and Validation: Essential for developing and validating robust, GLP-compliant analytical methods in regulatory bioanalysis.
• Drug Discovery & Development: Supports research into histamine receptor antagonists and modulators by providing a reliable quantitative tool.
• Quality Control in Diagnostics: Can be utilized in the development and calibration of in-vitro diagnostic (IVD) assays for histamine-related disorders.

Basic Information

Product Name	n-Tau-Methyl-D3-Histamine 2Hcl
CAS No.	344299-49-6
Molecular Formula	C6H10D3N3·2HCl
Molecular Weight	223.14 g/mol
Synonyms	Nτ-Methyl-D3-histamine dihydrochloride; 2-[2-(Methyl-d3-amino)ethyl]-1H-imidazole dihydrochloride; Histamine N-methyl-d3 dihydrochloride; Deuterated Histamine Methyl Derivative; Nτ-Methylhistamine-d3 2HCl; N-tele-Methylhistamine-d3 dihydrochloride; (1H-Imidazol-4-yl)ethyl(methyl-d3)amine dihydrochloride
EINECS	Contact for details

Quality Control

Our n-Tau-Methyl-D3-Histamine 2Hcl is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by MS), and impurity profile. We adhere to standards relevant for research and diagnostic use, and custom synthesis to meet specific purity or isotopic enrichment requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.