Description

Dl-Propranolol-D7 (Ring-D7) is a deuterium-labeled analog of the non-selective β-adrenergic receptor blocker, propranolol, specifically deuterated on the aromatic ring. This compound is an essential internal standard for the precise quantification of propranolol in complex biological matrices using advanced analytical techniques like LC-MS/MS and GC-MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Use as a stable isotope-labeled internal standard for the accurate quantification of propranolol in bioanalytical assays (e.g., LC-MS/MS, GC-MS).
• Critical tool in pharmaceutical research for conducting Absorption, Distribution, Metabolism, and Excretion (ADME) studies and pharmacokinetic profiling.
• Facilitates method development and validation in clinical and forensic toxicology for the detection of β-blockers.
• Enables high-precision metabolic pathway elucidation and drug interaction studies in preclinical research.
• Supports quality control and assurance processes in the manufacturing of propranolol and related pharmaceutical products.
• Applied in environmental and food safety testing for trace analysis of pharmaceutical residues.

Basic Information

Product Name	Dl-Propranolol-D7 (Ring-D7)
CAS No.	344298-99-3
Molecular Formula	C16H14D7NO2
Molecular Weight	266.38 g/mol (approx.)
Synonyms	Propranolol-d7 (ring-D7); (±)-Propranolol-d7; 1-[(1-Methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol-d7; DL-Propranolol D7; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol-d7; Deuterated Propranolol; Propranolol Internal Standard-d7
EINECS	Contact for details

Quality Control

Our Dl-Propranolol-D7 (Ring-D7) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment (HPLC), isotopic enrichment verification (NMR, MS), and chemical identification to ensure it meets the exacting standards required for use as a certified reference material. A detailed Certificate of Analysis (COA) specifying batch-specific data for purity, isotopic purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.