Description

4-(Ethenylsulfonyl)Benzoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is a specialized, high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group and a vinyl sulfone moiety. This dual functionality is critical for creating stable, covalent linkages in advanced bioconjugation and polymer synthesis applications. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostic, and advanced materials sectors who require precise and reliable cross-linking agents.

Application

• Bioconjugation Reagent: For the site-specific labeling and cross-linking of proteins, antibodies, peptides, and oligonucleotides, enabling the development of antibody-drug conjugates (ADCs), diagnostic probes, and immobilized enzymes.
• Polymer Functionalization: As a key monomer or cross-linker for synthesizing functional polymers, hydrogels, and smart materials with tailored properties for biomedical and separation technologies.
• Surface Modification: Used to create reactive coatings on glass, gold, or polymer surfaces for biosensor chips, microarray slides, and affinity chromatography media.
• Pharmaceutical Intermediate: Serves as a critical synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) and targeted therapeutic agents.
• Material Science Research: Employed in R&D for developing novel covalent organic frameworks (COFs), dendrimers, and other advanced nanostructured materials.

Basic Information

Product Name	4-(Ethenylsulfonyl)Benzoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	343934-41-8
Molecular Formula	C13H11NO6S
Molecular Weight	309.29 g/mol
Synonyms	4-Vinylsulfonylbenzoyloxy succinimide; 4-(Vinylsulfonyl)benzoic acid N-hydroxysuccinimide ester; NHS ester of 4-vinylsulfonylbenzoic acid; 4-(Ethenylsulfonyl)benzoic acid succinimidyl ester; 4-VSBA-NHS; Succinimidyl 4-(vinylsulfonyl)benzoate; 4-(Vinylsulfonyl)benzoyl NHS ester; 4-(Ethenylsulfonyl)benzoyloxysuccinimide
EINECS	Contact for details

Quality Control

Every batch of 4-(Ethenylsulfonyl)Benzoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive applications like bioconjugation. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.