Description

n-Boc 2-Acetyl-4-Bromoaniline is a high-purity, protected aniline derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the bromine and acetyl functional groups for structural diversity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Peptidomimetics & Bioconjugation: The Boc-protected amine is instrumental in peptide synthesis and the creation of bioconjugates for diagnostic applications.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Academic & Contract Research: A valuable reagent for method development and exploring new synthetic pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	n-Boc 2-Acetyl-4-Bromoaniline
CAS No.	341521-29-7
Molecular Formula	C₁₃H₁₆BrNO₃
Molecular Weight	314.18 g/mol
Synonyms	tert-Butyl (2-acetyl-4-bromophenyl)carbamate; 2'-Acetyl-4'-bromophenylcarbamic Acid tert-Butyl Ester; 4-Bromo-2-acetylphenylcarbamic Acid 1,1-Dimethylethyl Ester; 1-(4-Bromo-2-((tert-butoxycarbonyl)amino)phenyl)ethan-1-one; Boc-2-Acetyl-4-Bromo-Aniline; N-Boc-2-Acetyl-4-Bromoaniline; 2-Acetyl-4-bromo-N-Boc-aniline
EINECS	Contact for details

Quality Control

Our n-Boc 2-Acetyl-4-Bromoaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.