Description

2-Chloromethyl-1-Fluoro-3-Methoxybenzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine and chloromethyl groups can dramatically alter biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, contributing to improved performance and stability.
• Cross-Coupling Reactions: The chloromethyl group acts as a handle for further functionalization via palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig amination.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering physical properties for specialized coatings or membranes.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex heterocyclic compounds in academic and industrial R&D settings.

Basic Information

Product Name	2-Chloromethyl-1-Fluoro-3-Methoxybenzene
CAS No.	339586-05-9
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Fluoro-2-(chloromethyl)-3-methoxybenzene; 3-Methoxy-2-(chloromethyl)fluorobenzene; 2-(Chloromethyl)-1-fluoro-3-methoxybenzene; 1-Fluoro-3-methoxy-2-(chloromethyl)benzene; Benzene, 2-(chloromethyl)-1-fluoro-3-methoxy-; α-Chloro-2-fluoro-6-methoxytoluene
EINECS	Contact for details

Quality Control

Our 2-Chloromethyl-1-Fluoro-3-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.