Description

Panitumumab is a recombinant, fully human monoclonal antibody (IgG2) that specifically targets the epidermal growth factor receptor (EGFR). This targeted therapeutic agent is critical for inhibiting tumor cell proliferation and survival in EGFR-expressing cancers. It is primarily utilized by pharmaceutical manufacturers, biotechnology research organizations, and clinical laboratories engaged in oncology drug development and therapeutic applications.

Application

• Oncological Therapeutics: Primary active pharmaceutical ingredient (API) for the treatment of wild-type RAS metastatic colorectal cancer (mCRC).
• Biopharmaceutical Research: Key reagent in preclinical and clinical studies investigating EGFR pathway inhibition.
• Drug Formulation Development: Used in the development and scale-up of sterile injectable formulations (IV infusion).
• Combinatorial Therapy Studies: Investigated in combination with other chemotherapeutic agents for enhanced anti-tumor efficacy.
• Biosimilar Development: Reference standard for the analytical characterization and development of biosimilar candidates.

Basic Information

Product Name	Panitumumab
CAS No.	339177-26-3
Molecular Formula	C6398H9874N1698O2011S46
Molecular Weight	Approx. 147 kDa
Synonyms	ABX-EGF; Vectibix; Anti-EGFR Monoclonal Antibody ABX-EGF; rHuMAb-EGFR; Monoclonal Antibody ABX-EGF; Fully Human Anti-EGFR IgG2 Monoclonal Antibody; Panitumumab (USAN/INN); Anti-(Human EGFR) (Human-mouse Monoclonal ABX-EGF γ2-chain)
EINECS	Contact for details

Quality Control

Our Panitumumab is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting stringent specifications for biopharmaceutical active substances. A comprehensive Certificate of Analysis (COA) detailing results for appearance, protein content, biological activity (EGFR binding and inhibition), purity (SEC-HPLC, CE-SDS), charge variants (cIEF), and critical impurities (host cell proteins, DNA, endotoxins) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized powder at 2-8°C. Under these conditions, the product is stable for the period indicated on the label. Reconstituted or diluted solutions should be used immediately and are not intended for storage. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized cake or powder
Identification (HPLC/CE)	Conforms to reference standard
Protein Content (A280)	90% - 110% of label claim
Purity (SEC-HPLC)	≥ 98.0% Monomer
Purity (CE-SDS, Reduced)	Heavy Chain & Light Chain bands present; ≥ 95.0%
Potency (Cell-Based ELISA/Bioassay)	90% - 125% of reference
Endotoxins (LAL)	< 1.0 EU/mg
Host Cell Proteins (HCP ELISA)	< 100 ppm
Host Cell DNA (qPCR)	< 10 pg/mg
Moisture Content (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.