Description

Rovelizumab is a humanized monoclonal antibody designed to target specific cell adhesion molecules. This compound is of significant interest in advanced pharmaceutical research and development, particularly in the field of immunology. It is primarily utilized by research institutions and biopharmaceutical companies engaged in the discovery and preclinical evaluation of novel therapeutic agents for inflammatory and autoimmune conditions.

Application

• Immunological Research: Used as a key reagent in studying leukocyte adhesion and migration mechanisms.
• Drug Discovery: Serves as a reference standard or a lead candidate in the development of anti-inflammatory biologics.
• Preclinical Studies: Employed in animal models to investigate efficacy and pharmacokinetics for potential autoimmune disease therapies.
• Biomarker Development: Utilized in assay development for detecting and quantifying specific immune cell interactions.
• Process Development: Acts as a model molecule for optimizing upstream and downstream biomanufacturing processes for monoclonal antibodies.

Basic Information

Product Name	Rovelizumab
CAS No.	339086-79-2
Molecular Formula	Contact for details
Molecular Weight	Approx. 145-150 kDa
Synonyms	hu23F2G; Anti-CD11/CD18 Monoclonal Antibody; LeukArrest; Rovelizumab (USAN); Immunoglobulin G1, anti-(human antigen CD11a) (human-mouse monoclonal hu23F2G γ1-chain), disulfide with human-mouse monoclonal hu23F2G κ-chain, dimer
EINECS	Contact for details

Quality Control

Our Rovelizumab is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation, and determination of biological activity. A Certificate of Analysis (COA) detailing specifications and test results is provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE / SEC-HPLC)	≥ 95%
Protein Content (UV)	≥ 1.0 mg/vial
Endotoxin (LAL)	< 1.0 EU/mg
Biological Activity (Binding Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.