Description

n-Demethyl Vandetanib is a key pharmaceutical intermediate and metabolite of the tyrosine kinase inhibitor Vandetanib. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the synthesis and metabolic study of targeted cancer therapies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on oncology drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis and process development of Vandetanib and related kinase inhibitors.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies, pharmacokinetics (PK), and drug metabolism research.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control, ensuring the purity and safety of the final active pharmaceutical ingredient (API).
• Biochemical Research: Employed in in-vitro studies to investigate the structure-activity relationships (SAR) and metabolic pathways of tyrosine kinase inhibitors.
• Regulatory Compliance: Essential for generating data to meet regulatory submission requirements (e.g., FDA, EMA) for drug approval.

Basic Information

Product Name	n-Demethyl Vandetanib
CAS No.	338992-12-4
Molecular Formula	C21H22BrF2N4O2
Molecular Weight	473.33 g/mol
Synonyms	N-Desmethyl Vandetanib; Vandetanib N-Desmethyl; Vandetanib Impurity; ZD6474 N-Desmethyl; 4-(4-Bromo-2-fluorophenylamino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline N-Desmethyl; UNII-4J7G4T5LQ5; Vandetanib Metabolite; CP-724,714 N-Desmethyl (Related Compound)
EINECS	Contact for details

Quality Control

Our n-Demethyl Vandetanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets high-purity standards suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.