Description

Phosphine Oxide, [(2Z)-2-[(3R,5S)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Methylenecyclohexylidene]Ethyl]Diphenyl- is a sophisticated, high-value organophosphorus compound featuring a complex, stereodefined molecular architecture. This compound is a critical advanced intermediate in the synthesis of complex bioactive molecules, prized for its unique chemical functionality. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams working on novel therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct challenging carbon skeletons with high enantiomeric purity.
• Ligand Precursor: Serves as a precursor for specialized phosphine oxide ligands used in transition metal catalysis.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products with polycyclic structures.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Academic & Industrial Research: A valuable tool for chemists exploring new synthetic methodologies and reaction mechanisms.

Basic Information

Product Name	Phosphine Oxide, [(2Z)-2-[(3R,5S)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Methylenecyclohexylidene]Ethyl]Diphenyl-
CAS No.	338956-85-7
Molecular Formula	C37H59O3PSi2
Molecular Weight	639.02 g/mol
Synonyms	[(2Z)-2-[(3R,5S)-3,5-Bis[(tert-Butyldimethylsilyl)oxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; (Z)-[2-[(3R,5S)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; Diphenyl[(2Z)-2-[(3R,5S)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethyl]phosphine oxide; TBDMS-protected phosphine oxide intermediate; Chiral phosphine oxide silyl ether
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and structural integrity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali conditions. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.