Description

Ethyl 5-Methyl-4-([3-(Trifluoromethyl)Anilino]Carbonyl)-3-Isoxazolecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical synthesis specialists.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Agrochemical Research: Serves as a precursor in the development of new generation pesticides and herbicides, leveraging the biological activity of the isoxazole and trifluoromethylphenyl motifs.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop compounds with improved efficacy and pharmacokinetic profiles.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex molecules for academic and industrial research purposes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.

Basic Information

Item	Details
Product Name	Ethyl 5-Methyl-4-([3-(Trifluoromethyl)Anilino]Carbonyl)-3-Isoxazolecarboxylate
CAS No.	338761-34-5
Molecular Formula	C15H13F3N2O4
Molecular Weight	342.27 g/mol
Synonyms	Ethyl 5-methyl-4-({[3-(trifluoromethyl)phenyl]carbamoyl})isoxazole-3-carboxylate; 3-Isoxazolecarboxylic acid, 4-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]-5-methyl-, ethyl ester; 338761-34-5; 4-[(3-Trifluoromethylphenyl)carbamoyl]-5-methylisoxazole-3-carboxylic acid ethyl ester; Ethyl 5-methyl-4-[(3-trifluoromethylphenyl)carbamoyl]isoxazole-3-carboxylate; 5-Methyl-4-({[3-(trifluoromethyl)phenyl]amino}carbonyl)isoxazole-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Methyl-4-([3-(Trifluoromethyl)Anilino]Carbonyl)-3-Isoxazolecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring ICH stability guidelines or cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.