Description

n-(5-Bromo-2-Methylphenyl)-2,2,2-Trifluoroacetamide is a high-purity, advanced pharmaceutical intermediate characterized by its brominated and trifluoroacetylated aromatic structure. This compound is critical for enabling precise chemical modifications in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the bromine and trifluoromethyl groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers and liquid crystals, leveraging its aromatic and halogenated properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a protected aniline derivative in multi-step synthetic sequences.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-(5-Bromo-2-Methylphenyl)-2,2,2-Trifluoroacetamide
CAS No.	338451-90-4
Molecular Formula	C9H7BrF3NO
Molecular Weight	282.06 g/mol
Synonyms	2,2,2-Trifluoro-N-(5-bromo-2-methylphenyl)acetamide; 5'-Bromo-2'-methyltrifluoroacetanilide; N-(5-Bromo-o-tolyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoroacetamide, N-(5-bromo-2-methylphenyl)-; 338451-90-4; 5-Bromo-2-methylphenyl trifluoroacetamide; Trifluoroacetic acid (5-bromo-2-methylphenyl)amide
EINECS	Contact for details

Quality Control

Our n-(5-Bromo-2-Methylphenyl)-2,2,2-Trifluoroacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.