Description

2-((1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)Methylene)Malononitrile is a high-value, structurally complex organic intermediate featuring a fused indole-pyridine core with chloro and trifluoromethyl substituents. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique electronic and steric properties are leveraged. It is primarily needed by research institutions and industrial manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors for developing novel compounds with targeted biological or functional activities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Organic Light-Emitting Diodes (OLEDs): Acts as an electron-transport or host material in the fabrication of high-efficiency OLED devices due to its conjugated system.
• Material Science: Employed in the synthesis of advanced polymers and dyes with specific optical or electronic properties.
• Chemical Biology Probe: Utilized in academic and industrial research to create molecular probes for studying enzyme function and biological pathways.
• Ligand Synthesis: Functions as a starting material for creating complex ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	2-((1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)Methylene)Malononitrile
CAS No.	338409-96-4
Molecular Formula	C20H8ClF3N4
Molecular Weight	396.75 g/mol
Synonyms	2-[(1-{3-Chloro-5-(trifluoromethyl)pyridin-2-yl}-1H-indol-3-yl)methylene]propanedinitrile; 2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile; 338409-96-4; Malononitrile, 2-((1-(3-chloro-5-(trifluoromethyl)-2-pyridinyl)-1H-indol-3-yl)methylene)-; (2Z)-2-[(1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}indol-3-yl)methylidene]propanedinitrile
EINECS	Contact for details

Quality Control

Our 2-((1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)Methylene)Malononitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.