Description

Boc-o-Benzyl-L-β-Homohydroxyproline Dicyclohexylamine Salt is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This protected proline analog is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Drug Discovery: Used to introduce conformational constraints and enhance metabolic stability in peptide analogs for therapeutic development.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block for the automated synthesis of complex peptide sequences.
• Protease Inhibitor Research: Employed in the design and development of inhibitors for enzymes like prolyl oligopeptidase.
• Chemical Biology Probes: Utilized to create labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Process Chemistry & Scale-Up: Supports route development and optimization for the commercial manufacturing of peptide drugs.

Basic Information

Product Name	Boc-o-Benzyl-L-β-Homohydroxyproline Dicyclohexylamine Salt
CAS No.	336182-09-3
Molecular Formula	C28H44N2O5
Molecular Weight	488.66 g/mol
Synonyms	(2S,4S)-1-[(tert-Butoxy)carbonyl]-4-(benzyloxy)-2-piperidinecarboxylic Acid Dicyclohexylamine Salt; Boc-4-OBn-L-homoHyp-OH·DCHA Salt; N-Boc-O-benzyl-L-β-homohydroxyproline Dicyclohexylammonium Salt; tert-Butyl (2S,4S)-4-(benzyloxy)-2-(carboxy)piperidine-1-carboxylate Dicyclohexylamine Salt; Boc-O-Bzl-L-β-Hyp-OH DCHA Salt; Fmoc/Boc Protected Amino Acid Derivative; Protected Homoproline Analog
EINECS	Contact for details

Quality Control

Our Boc-o-Benzyl-L-β-Homohydroxyproline Dicyclohexylamine Salt is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to high-purity standards suitable for pharmaceutical R&D, with typical purity levels exceeding 98% (by HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.