Description

Boc-L-β-Homoglutamine CAS NO 336182-06-0 is a protected amino acid derivative, specifically an N-Boc derivative of L-β-homoglutamine. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) and solution-phase methods to incorporate the β-homoglutamine residue with orthogonal protection.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to modify peptide backbones and explore new pharmacophores.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Proteomics & Biochemical Tools: Used in the preparation of enzyme substrates, inhibitors, or labeled peptides for biochemical assays.
• Academic Research: A valuable reagent for university and institutional labs studying peptide chemistry and amino acid derivatives.

Basic Information

Product Name	Boc-L-β-Homoglutamine
CAS No.	336182-06-0
Molecular Formula	C₁₁H₂₀N₂O₆
Molecular Weight	276.29 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-5-carbamoylpentanoic acid; N-(tert-Butoxycarbonyl)-L-β-homoglutamine; Boc-β-hGln-OH; Boc-L-β-homo-Gln-OH; tert-Butyloxycarbonyl-L-β-homoglutamine; N-Boc-L-β-homoglutamine; (S)-2-((tert-Butoxycarbonyl)amino)-5-carbamoylpentanoic acid
EINECS	Contact for details

Quality Control

Our Boc-L-β-Homoglutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for purity, optical rotation, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.